Margolis’ imagery is inspired by the Zen Buddhist symbol, Enso; Japanese for circle, the embodiment of infinity and perfection. Attracted to its mystical elements, as well as the paradox for imperfection, she reinterprets the Enso's circular form in both positive and negative space.

After receiving her BS from Colorado State University in Psychology, Margolis studied at the Art Student’s League, Parsons School of Design, the School of Visual Arts and the New York Microscopical society. It was during her studies in Microscopy that Margolis was inspired to diverge from her traditional studies in figurative art to create work exploring the universality of macro/micro patterns.

Residing in New York City, Margolis’ work is exhibited internationally. She has an upcoming exhibition at the Pierro Gallery in New Jersey, honoring Tony Smith's 100th birthday. Margolis’ work has recently been featured at Rockland Center for the Arts, The Hunterdon Art Museum in New Jersey, University of North Carolina and at the Wexler Gallery in Philadelphia. Prior exhibitions include the Weatherspoon Art Museum, The Aldrich Museum of Contemporary Art and the Fine Arts Center of the University of Massachusetts in Amherst as well as McKenzie Fine Art, Jose Bienvenue Gallery and Slate Gallery in New York City. Solo exhibitions include Slate Gallery and Dieu Donne in New York City and The Delaware Center for Contemporary Art.

Margolis received a Pollock-Krasner Foundation Grant in 1998 and in 2000 designed a critically acclaimed set design for an Off-Broadway Play. That same year she received a workspace residency at Dieu Donne Papermill. She was instrumental in creating the Dr. Seuss Exhibit at the Children’s Museum of Manhattan. In 2004 she conceived and implemented a program to teach studio art to blind and visually impaired teenagers at The Lighthouse International.